SOLUTIONS / PHARMA INTERMEDIATES
Pharma intermediates supplier
with the paperwork up front.
We source process intermediates for generic APIs, Carbomer 940 and 980 thickeners, and selected bulk APIs from a vetted network of GMP-compliant manufacturers. Every product is listed by CAS number, and the documents you need for qualification are shared before the order is confirmed.
In short
What Rispri supplies to pharma manufacturers.
Rispri Labs is a pharma intermediates supplier in India that sources and trades three groups of products: process intermediates (building blocks for generic APIs such as imatinib, nilotinib, osimertinib, sitagliptin and vilanterol, each identified by CAS number), Carbomer 940 and Carbomer 980 (cross-linked polyacrylic acid thickeners for gels, creams and ointments) and bulk APIs available on enquiry. Products come from GMP-compliant partner manufacturers; we do not synthesise them in house. The standard minimum order for a listed intermediate is 10 kg, and the certificate of analysis, technical data sheet, MSDS and any available DMF or CEP status are shared before you confirm the order.
- 40+
- CAS-listed intermediates and excipients
- 18APIs
- Target molecules the intermediates are grouped under
- 10kg
- Standard minimum order per listed intermediate
- 20
- Bulk APIs available on enquiry
The basics
Intermediates, KSMs, APIs and excipients: what each one is.
A medicine starts as a chain of chemical steps. The key starting material (KSM) is the first significant building block that becomes part of the final drug molecule. Each compound made along the route after that is a pharmaceutical intermediate. The last step gives the active pharmaceutical ingredient (API), the substance that has the therapeutic effect. A formulator then mixes the API with excipients, the inactive ingredients that turn it into a tablet, capsule, gel or injection.
When you buy an intermediate, the CAS number matters more than the name. The same compound can be written several ways (for example "4-Chloro-3-(trifluoromethyl)phenyl isocyanate" is one building block shared by sorafenib and regorafenib routes), and a CAS Registry Number is a unique identifier that removes the guesswork. That is why every product on this page is listed with its CAS number.
Why a second source matters now
Indian formulators still import most of their APIs and key starting materials from a single country. According to published estimates, about 70% of India's API imports come from China, and API and bulk drug imports were about ₹37,722 crore in 2023-24. The government's production-linked incentive (PLI) scheme for bulk drugs covers 41 products, and 26 APIs, KSMs and intermediates are now made in India under it (source: Policy Circle, India's API dependence). Price swings and supply shocks have shown the cost of one-source risk. A second, well documented source protects your production plan.
Where Rispri fits
Alongside our environmental laboratory and water treatment businesses, Rispri Labs connects generic API manufacturers, CDMOs and formulation houses with a vetted network of manufacturing partners. We qualify more than one manufacturer for each building block where we can, collect the documents, and handle the commercial side so your purchase team deals with one accountable supplier.
Process intermediates
CAS-listed building blocks, grouped by target molecule.
Sourced against confirmed synthetic routes for oncology, metabolic, respiratory and CNS molecules. Standard minimum order is 10 kg per intermediate; larger volumes and custom routes are quoted on enquiry. Use your browser's find (Ctrl+F) to search by name or CAS number.
Oncology and kinase inhibitors
| Chemical name | CAS No. | Target API | Notes |
|---|---|---|---|
| N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine | 1421372-66-8 | Osimertinib | EGFR inhibitor for lung cancer |
| Methyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate | 917392-54-2 | Nilotinib | BCR-ABL inhibitor for CML |
| 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester | 641569-97-3 | Nilotinib | Ethyl ester of the acid below |
| 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid | 641569-94-0 | Nilotinib | |
| 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline | 641571-11-1 | Nilotinib | |
| N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine | 152460-09-8 | Imatinib | Nitro precursor of the amine below |
| N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine | 152460-10-1 | Imatinib | |
| 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride | 106261-49-8 | Imatinib | Dihydrochloride salt |
| 4-(4-Aminophenoxy)-N-methylpicolinamide | 284462-37-9 | Sorafenib | Multi-kinase inhibitor |
| 4-Chloro-3-(trifluoromethyl)phenyl isocyanate | 327-78-6 | Sorafenib | Also used for regorafenib; isocyanate, keep dry |
| 4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide | 757251-39-1 | Regorafenib | Fluoro analogue of the sorafenib amine |
| 4-Chloro-3-(trifluoromethyl)phenyl isocyanate | 327-78-6 | Regorafenib | Same product as listed under sorafenib |
| 4-Chloro-7-methoxyquinoline-6-carboxamide | 417721-36-9 | Lenvatinib | |
| 1-(2-Chloro-4-hydroxyphenyl)-3-cyclopropylurea | 796848-79-8 | Lenvatinib | |
| Methyl 2-(bromomethyl)-3-nitrobenzoate | 98475-07-1 | Lenalidomide | Immunomodulator for multiple myeloma |
| 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione | 827026-45-9 | Lenalidomide | Nitro precursor of lenalidomide |
| 2-Methyl-3-nitrobenzoic acid | 1975-50-4 | Lenalidomide | |
| Methyl 2-methyl-3-nitrobenzoate | 59382-59-1 | Lenalidomide | Methyl ester of the acid above |
| 4-Bromo-2-chloro benzonitrile | 154607-01-9 | Darolutamide | Androgen receptor antagonist |
| 1,1-Thiocarbonyldiimidazole | 6160-65-2 | Tucatinib | Moisture-sensitive reagent |
| 4-Amino-2-(trifluoromethyl)benzonitrile | 463-71-8 | Bicalutamide / Enzalutamide | Prostate cancer APIs |
| N-(4-Cyano-3-(trifluoromethyl)phenyl)methacrylamide | 90357-53-2 | Bicalutamide / Enzalutamide | |
| 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile | 143782-23-4 | Bicalutamide / Enzalutamide |
Metabolic and cardio-renal
| Chemical name | CAS No. | Target API | Notes |
|---|---|---|---|
| 1-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione | 764667-65-4 | Sitagliptin | DPP-4 inhibitor for type 2 diabetes |
| 2-Phenylethyl isocyanate | 1943-82-4 | Glimepiride | Isocyanate, keep dry |
| Trans-4-methylcyclohexyl isocyanate | 32175-00-1 | Glimepiride | Isocyanate, keep dry |
| N-Hexyl chloroformate | 6092-54-2 | Dabigatran | Chloroformate, moisture-sensitive |
| Chlorocarbonyl sulfenyl chloride | 2757-23-5 | Fezolinetant | Reactive acid chloride, moisture-sensitive |
| 5-Methyl-1,3,4-oxathiazole-5-one | 17452-74-3 | Fezolinetant | |
| 3-Methyl-1,2,4-thiadiazole-5-carbohydrazide | 1375066-73-1 | Fezolinetant |
Respiratory
| Chemical name | CAS No. | Target API | Notes |
|---|---|---|---|
| 1-(8-(Benzyloxy)-2-hydroxyquinolin-5-yl)-2-bromoethanone | 100331-89-3 | Indacaterol Maleate | Long-acting bronchodilator for COPD |
| 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride | 312753-53-0 | Indacaterol Maleate | Hydrochloride salt |
| (R)-8-(Benzyloxy)-5-(2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)quinolin-2(1H)-one | 435273-75-9 | Indacaterol Maleate | Single (R) enantiomer |
| (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one | 452339-73-0 | Vilanterol Trifenatate | Long-acting bronchodilator |
| (R)-3-(6-(2-((2,6-Dichlorobenzyl)oxy)ethoxy)hexyl)-5-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one | 503068-36-8 | Vilanterol Trifenatate | Single (R) enantiomer |
| (1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol | 503068-37-9 | Vilanterol Trifenatate | Single (1R) enantiomer |
CNS, dermatology and building blocks
| Chemical name | CAS No. | Target API | Notes |
|---|---|---|---|
| Bis(4-nitrophenyl) carbonate | 5070-13-3 | Rivastigmine / Solifenacin | Carbonylating reagent |
| O-2-Naphthyl chlorothioformate (25% in toluene) | 10506-37-3 | Tolnaftate | Supplied as a 25% solution in toluene |
| 4′-Chloroacetophenone | 99-91-2 | General organic synthesis building blocks | |
| Phenyl chlorothiocarbonate | 1005-56-7 | General organic synthesis building blocks | Moisture-sensitive |
| Cyanogen bromide | 506-68-3 | General organic synthesis building blocks | Highly toxic; special packing and transport |
Target API shows the molecule each intermediate is grouped under. Purity, assay and impurity limits are confirmed on the certificate of analysis for each lot. Handling notes are general; follow the MSDS supplied with the product.
Send the name, CAS number, quantity and target API. We check our partner network for the compound and for custom-route synthesis, and come back with availability and documents.
Specialty excipients
Carbomer 940 and Carbomer 980 rheology modifiers.
Carbomers are high molecular weight, cross-linked polyacrylic acid polymers. As supplied they are acidic, fluffy white powders; when dispersed in water and neutralised with a base, the polymer chains uncoil and swell, turning the liquid into a clear, thick gel. They are used as thickeners, suspending agents and stabilisers in pharmaceutical gels, oral care and personal care products.
| Property | Carbomer 940 | Carbomer 980 |
|---|---|---|
| Common name | Polyacrylic acid | Polyacrylic acid |
| CAS No. | 9003-01-4 | 9003-01-4 |
| HSN code | 39069090 | 39069090 |
| Appearance | White, fluffy powder | White, fluffy powder |
| Viscosity (0.5% w/v) | 40,000 to 60,000 cPs | 40,000 to 60,000 cPs |
| Assay | 56.0% to 68.0% | 56.0% to 68.0% |
| pH | 2.7 to 3.0 | 2.7 to 3.0 |
| Loss on drying | NMT 2.0% | See TDS |
| Clarity (0.5% w/v) | See TDS | ≥90% |
| Documents | TDS · MSDS | TDS · MSDS |
High viscosity, sparkling clear gels
An efficient rheology modifier that gives high viscosity and forms sparkling clear water or hydroalcoholic gels and creams. It is a proven thickener and stabiliser across personal care and pharmaceutical formulations.
Higher clarity, finer viscosity control
A synthetic, cross-linked polyacrylate polymer, made by a benzene-free process, offering higher clarity and finer viscosity control than 940. Typical applications: hair styling gel, hydro-alcoholic gel, moisturising cream, sunscreen lotion, toothpaste, shampoo, pharma gels and ointments, and skin fresheners.
How to get a clear carbomer gel
- Disperse slowly. Sift the powder into the vortex of well-stirred water. Dumping it in forms lumps ("fish eyes") with dry powder trapped inside.
- Let it wet out. Allow the dispersion to hydrate fully before neutralising; it will look cloudy and thin at this stage.
- Neutralise. Add a base such as sodium hydroxide or triethanolamine while stirring gently. Viscosity rises sharply as the pH moves towards neutral.
- Avoid air. Mix slowly after neutralising to keep bubbles out of a clear gel.
Bulk APIs
Active pharmaceutical ingredients available on enquiry.
From time to time, bulk quantities of the APIs below become available through our sourcing network. Availability, batch documentation and lot size are confirmed at the time of enquiry.
| API | Grade listed | Therapeutic class (general) |
|---|---|---|
| Methylprednisolone Hemisuccinate | On enquiry | Corticosteroid |
| Darunavir | On enquiry | HIV protease inhibitor |
| Phenoxybenzamine Hydrochloride | On enquiry | Alpha-adrenergic blocker |
| Temazepam | USP | Benzodiazepine (controlled substance) |
| Mycophenolate Mofetil | USP | Immunosuppressant |
| Succinylcholine Chloride | On enquiry | Neuromuscular blocker |
| Calcium Levofolinate | On enquiry | Folate (leucovorin) rescue |
| Eltrombopag Olamine | On enquiry | Thrombopoietin receptor agonist |
| Entecavir | USP | Hepatitis B antiviral |
| Tiopronin | On enquiry | Used in cystinuria |
| Desipramine Hydrochloride | USP | Tricyclic antidepressant |
| Clomipramine Hydrochloride | USP | Tricyclic antidepressant |
| Raloxifene Hydrochloride | USP | Selective oestrogen receptor modulator |
| Felbamate | USP | Antiepileptic |
| Teriflunomide | On enquiry | Multiple sclerosis therapy |
| Ephedrine Sulfate | USP | Sympathomimetic (controlled precursor) |
| Exenatide | On enquiry | GLP-1 receptor agonist (peptide) |
| Phenylephrine Hydrochloride | USP | Alpha-adrenergic agonist |
| Norepinephrine Bitartrate | USP | Vasopressor |
| Dexmedetomidine Hydrochloride | USP | Alpha-2 agonist sedative |
"USP" is shown where the grade is listed. Narcotic, psychotropic and precursor substances can only be supplied to buyers holding the licences required under Indian law, and export or import needs the matching permits. Ask us before you plan around any of these.
Documentation
The documents you get, and what each one tells you.
COA, TDS, MSDS and available regulatory filings are shared for every enquiry before order confirmation, so your QA team can review them before money changes hands.
| Document | What it is | Why your QA team needs it |
|---|---|---|
| Certificate of analysis (COA) | Test results for a specific batch against its specification: identity, assay, impurities, water or loss on drying. | Proves the lot you receive meets the agreed specification; it is matched to the batch number on the drum. |
| Technical data sheet (TDS) | Typical properties and the product specification. | Lets R&D check fit before ordering samples. |
| Material safety data sheet (MSDS / SDS) | Hazards, safe handling, storage, spill and fire response, transport classification. | Required for safe storage and handling at your site and for transport. |
| DMF / CEP status (where applicable) | A Drug Master File is a confidential dossier on how an API or intermediate is made, filed with a regulator. A CEP is a Certificate of Suitability issued for Ph. Eur. monographs. | Needed when your own product is filed in regulated markets that reference the supplier's dossier. |
Verified manufacturing partners
Every intermediate and API is sourced from GMP-compliant manufacturers within our vetted partner network, not synthesised in house.
Pre-shipment checks
Quality varies from lot to lot at some sources. We run pre-shipment checks, with testing in our own laboratory on request.
Flexible lot sizes
From sample quantities for development to regular supply for production, so you do not need to change supplier when you scale up.
How to order
From enquiry to delivery in five steps.
- 1
Send your list
Product name, CAS number, quantity in kg, grade and the target API or use.
- 2
Availability and documents
We confirm source, lot size and price, and share COA, TDS, MSDS and regulatory status.
- 3
Sample if needed
Sample quantities for your R&D or QA to qualify the material.
- 4
Order
Purchase order against the agreed specification; 10 kg minimum for listed intermediates.
- 5
Check and dispatch
Pre-shipment check, batch COA with the consignment, delivery to your site.
| Item | Listed intermediates | Custom route or bulk API |
|---|---|---|
| Minimum order | 10 kg per intermediate | Quoted per enquiry |
| Samples | Sample quantities on request | Depends on availability |
| Lead time | Confirmed with the quotation | Confirmed with the quotation |
| Price | Quoted per enquiry; depends on quantity and grade | Quoted per enquiry |
Quality and regulation
The rules your auditors check.
Pharmaceutical quality in India rests on the Drugs and Cosmetics Act, 1940 and its rules, administered by the Central Drugs Standard Control Organisation (CDSCO) and state drug controllers. Good manufacturing practice is set out in Schedule M, which was revised in 2023 to bring it closer to WHO GMP. For APIs, the international reference is ICH Q7, the GMP guide for active pharmaceutical ingredients, which applies from the point where the API starting material enters the process.
That is why the source of an intermediate matters. If a building block is used after the API starting material, its manufacture falls inside your GMP story, and your auditors will want to see that the supplier is qualified, that specifications are agreed and that changes are notified.
Sourcing risks
Common sourcing problems, and how we reduce them.
- 01The problem
One supplier and one country for a critical molecule.
What we doWe qualify more than one manufacturer for each building block, so a shutdown at one source does not stop your line.
- 02The problem
Documents arrive late or are incomplete.
What we doCOA, TDS and regulatory status are shared before the order, not after the goods arrive.
- 03The problem
Quality varies from lot to lot.
What we doPre-shipment checks against the agreed specification, and our own laboratory testing on request.
- 04The problem
Development needs small lots, production needs scale.
What we doFlexible lot sizes from sample quantities to regular supply from the same qualified source.
- 05The problem
Names on the purchase order do not match the supplier's label.
What we doEvery line is quoted and invoiced against its CAS number, so there is no doubt about what is being supplied.
Who we supply
Built for the teams that depend on it.
Generic API manufacturers
Second sources for intermediates on established routes.
Formulators
Carbomer 940 and 980 for gels, creams and ointments, plus APIs on enquiry.
Contract manufacturers
Building blocks for client projects, with documents for tech transfer.
R&D laboratories
Sample quantities to develop and qualify a route before scale-up.
Pharma effluent is high in COD, solvents and salts, and many units must reach zero liquid discharge. Our engineering team designs and runs ETP and ZLD plants for pharma units, and our NABL-accredited laboratory tests the effluent.
Buying guide
What to ask any intermediates supplier.
Use this list with any supplier, including us.
- Is the CAS number on the quote and the invoice? It is the only unambiguous identity check.
- Can I see the COA before I order? Ideally a recent batch COA against the specification you will buy to.
- Who actually makes it? A trader should tell you whether the manufacturer is GMP-compliant and whether it can be audited.
- Is there a DMF or CEP? Needed if your product is filed in regulated markets.
- What happens if the route or site changes? Ask for change notification in writing.
- Can I get a sample from the same source as the commercial lot? Otherwise your qualification work may not hold.
- How is it packed and shipped? Especially for isocyanates, chloroformates and toxic reagents.
- Is there a second source? One plant is one point of failure.
Why Rispri
One accountable supplier for your CAS list.
Documents before the order
COA, TDS, MSDS and DMF/CEP status where applicable, shared before you commit.
Vetted partner network
GMP-compliant manufacturers, with more than one source qualified for each building block where possible.
Our own laboratory
Pre-shipment checks and testing in our own laboratory on request.
In business since 1999
An Indian engineering and laboratory company with offices in Jaipur, Agra and Ahmedabad.
Questions
Pharma intermediates FAQs.
What is a pharmaceutical intermediate?
A pharmaceutical intermediate is a compound made during the synthesis of an active pharmaceutical ingredient (API) that is converted further before it becomes the final API. Intermediates sit between the key starting material and the finished API in the synthetic route.
Why do you list products by CAS number?
A CAS Registry Number is a unique identifier for a chemical substance. Long chemical names can be written in several ways, so quoting and invoicing against the CAS number makes sure you get exactly the compound you asked for.
What is the minimum order quantity?
The standard minimum order for a listed process intermediate is 10 kg. Larger volumes, custom-route intermediates and bulk API lots are quoted per enquiry.
Can I get a sample before ordering?
Yes. We supply from sample quantities for development up to regular production supply. Tell us the quantity your R&D or QA needs to qualify the material.
Which documents do you provide?
A certificate of analysis (COA), technical data sheet (TDS) and material safety data sheet (MSDS) are available for all products, along with DMF or CEP status where applicable. They are shared before order confirmation.
Do you manufacture these intermediates yourselves?
No. Rispri Labs sources intermediates and APIs from GMP-compliant manufacturers in a vetted partner network. We handle qualification of sources, documents, pre-shipment checks and supply.
Do you supply Carbomer 940?
Yes. We supply Carbomer 940 (polyacrylic acid, CAS 9003-01-4, HSN 39069090), with a typical viscosity of 40,000 to 60,000 cPs at 0.5% w/v. The TDS and MSDS can be downloaded from this page.
What is the difference between Carbomer 940 and Carbomer 980?
Both are cross-linked polyacrylic acid polymers with similar viscosity. Carbomer 980 is made by a benzene-free process and gives higher clarity and finer viscosity control, with clarity of at least 90% at 0.5% w/v, which suits clear gels and pharma ointments.
What are carbomers used for?
Carbomers are used as thickeners, suspending agents and stabilisers. Typical uses include pharmaceutical gels and ointments, hydro-alcoholic gels, creams, sunscreens, toothpaste, shampoo and hair styling gels.
Which APIs can you supply?
We list 20 bulk APIs available on enquiry, including Darunavir, Entecavir USP, Mycophenolate Mofetil USP, Teriflunomide and Dexmedetomidine Hydrochloride USP. Availability, batch documents and lot size are confirmed when you enquire.
Which pharmacopoeia grades do you supply?
IP, BP, USP and EP grades are supplied as specified, depending on the product and source. State the grade you need in your enquiry so that the COA is issued against the right monograph.
How is the material packed?
Packing depends on the product and quantity and is confirmed with the quotation. Reactive or toxic materials such as isocyanates, chloroformates and cyanogen bromide are packed and transported according to their MSDS and transport classification.
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